The Movement Disorder Society

MDS 18th International Congress of Parkinson's Disease and Movement Disorders, Volume 29,
June 2014 Abstract Supplement

Movement Disorders 2014
Stockholm, Sweden June 8-12, 2014.


Clinical features and neuropsychological profile in vascular Parkinsonism

Benítez-Rivero,  S., Lama,  M.J., Huertas-Fernández,  I., Álvarez-de-Toledo,  P., Cáceres-Redondo,  M.T., Carrillo,  F., Carballo,  M., Palomar,  F.J., Mir,  P.

Seville, Spain

Objective:

To evaluate the clinical characteristics, the neuropsychiatric features and the profile of cognitive impairment in patients with vascular parkinsonism (VP).

Background:

The clinical profile in VP patients is well described in the literature, but little is known about the neuropsychiatric and neuropsychological features of this disease. One of the few exiting studies have found that the neuropsychiatric disturbances do not differ significantly between VP and Parkinson's disease (PD) and that VP patients have a more severe executive dysfunction in the neuropsychological exam.

Methods:

We prospectively evaluated 12 patients with VP, 15 with PD and 13 healthy subjects with similar age and sex distribution. Different clinical and demographic details were collected. All subjects underwent detailed neurological, neuropsychiatric and neuropsychological examinations. The neuropsychological tests included analysis of global efficiency, executive function, verbal memory, language and visuospatial function.

Results:

VP patients exhibited lower disease duration, older age at onset and higher frequency of cardiovascular risk factors. Non-motor symptoms, sleepiness and impulse control disorders were found to be more frequent in PD. We found that VP patients developed cognitive impairment with a significantly higher frequency than healthy subjects of a similar age. Additionally, we found that these patients had a global pattern of cognitive impairment, including executive function, verbal memory and language. Only visuospatial function was more impaired in PD than in healthy subjects.

Conclusions:

Our data contribute to clarify the pattern of neuropsychiatric and neuropsychological impairment in VP. Therefore, in the clinical evaluation, besides assessing the motor status of the patient, given that these symptoms are frequently found not to be self-reported complaints, the neurologist should evaluate them routinely as a comprehensive assessment of this disease.

To cite this abstract, please use the following information:
Benítez-Rivero, S., Lama, M.J., Huertas-Fernández, I., Álvarez-de-Toledo, P., Cáceres-Redondo, M.T., Carrillo, F., Carballo, M., Palomar, F.J., Mir, P.; Clinical features and neuropsychological profile in vascular Parkinsonism [abstract]. Movement Disorders 2014;29 Suppl 1 :269